関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ethylmorpholine | HCID 7525 | — |
| 反応物 | 3-Hydroxypicolinic Acid | HCID 13401 | — |
| 反応物 | 1-Hydroxybenzotriazole | HCID 75771 | — |
| 反応物 | N-cyclohexyl-N'-(2-morpholinoethyl)-carbodiimide methyl-p-toluenesulfonate | HCID 9954069 | — |
| 反応物 | Glycine 1-dodecyl ester tosylate | HCID 15435490 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 3-Hydroxypyridine-2-carboxylic acid N-(((1-dodecyloxy)carbonyl)methyl)amide | HCID 9842011 | — |
反応手順
7 g (50 mmol) of 3-hydroxypyridine-2-carboxylic acid were suspended in 800 ml of anhydrous dichloromethane and treated with 7.5 g (55 mmol) of 1-hydroxy-1H-benzotriazole, 19.2 ml (150 mmol) of N-ethylmorpholine, 21.2 g (50 mmol) of N-cyclohexyl-N'-(2-morpholinoethyl)carbodiimide methyl-p-toluenesulfonate (CMC) and 20.8 g (50 mmol) of glycine 1-dodecyl ester tosylate and the mixture was stirred at 20° C. for 50 h.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06020350 |
|---|
| 出典データセット | uspto-grants-2000_02 |
|---|
| ORD ID | ord-015e862b3cb0448ab6bfcf1d5e1d4c92 |
|---|
| 出典メモ | uspto-grants-2000_02 |
|---|
