関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Nitric Acid | HCID 944 | — |
| 反応物 | Sulfuric Acid | HCID 1118 | — |
| 反応物 | p-Fluorotoluene | HCID 9603 | — |
| 生成物 | 4-Fluoro-2-nitrotoluene | HCID 67965 | 81.1% |
反応手順
4-Fluorotoluene (14 g) is added slowly with stirring to a solution of fuming nitric acid (18 g) and concentrated sulfuric acid (30 g) over 30 minutes and alternately warmed and cooled to keep the temperature between 40 and 50° C. This is followed by heating at 100° C. for 30 minutes more. The organic material is cooled and extracted with methylene chloride to give 16 g of 4-fluoro-2-nitrotoluene.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06020379 |
|---|
| 出典データセット | uspto-grants-2000_02 |
|---|
| ORD ID | ord-2ee120e614af43e9892804db6475cb6a |
|---|
| 出典メモ | uspto-grants-2000_02 |
|---|
