Dichloromethane → 1-Cycloheptyl-1-(6,7,8,9-tetrahydro-5H-benzocyclohepten-5-yl)-3-[p-(N,N-dimethylamino)phenyl]urea monohydrochloride

HRID 37645

反応式

HRID 37645 の反応式
[CH:1]1([NH:8][C:9]2[C:14]3[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][C:13]=3[CH:12]=[CH:11][CH:10]=2)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:20][N:21]([C:23]1[CH:28]=[CH:27][C:26]([N:29]=[C:30]=[O:31])=[CH:25][CH:24]=1)[CH3:22].[Cl:32]CCl>>[ClH:32].[CH:1]1([N:8]([CH:9]2[C:10]3[CH:11]=[CH:12][CH:13]=[CH:19][C:18]=3[CH2:17][CH2:16][CH2:15][CH2:14]2)[C:30]([NH:29][C:26]2[CH:27]=[CH:28][C:23]([N:21]([CH3:22])[CH3:20])=[CH:24][CH:25]=2)=[O:31])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7]1

参加物

4

反応物 3

HCID 6344DichloromethaneHCID 27333724-(Dimethylamino)phenyl isocyanateHCID 19936134N-Cycloheptyl-(6,7,8,9-tetrahydro-5H-benzocycloheptenyl)amine

生成物 1

HCID 197856731-Cycloheptyl-1-(6,7,8,9-tetrahydro-5H-benzocyclohepten-5-yl)-3-[p-(N,N-dimethylamino)phenyl]urea monohydrochloride

実験手順

N-Cycloheptyl-(6,7,8,9-tetrahydro-5H-benzocycloheptenyl)amine (0.8 g, 3.1 mmol) and 4-(N,N-dimethyamino)phenylisocyanate (0.50 g, 3.1 mmol) was stirred in dichloromethane (10 ml) at room temperature for 18 hrs. The reaction mixture was then purified by silica gel column chromatography. The resulting urea compound was treated with hydrochloric acid in ether to give 0.72 g of the above hydrochloride compound.

後処理

  1. customThe reaction mixture was then purified by silica gel column chromatography
  2. additionThe resulting urea compound was treated with hydrochloric acid in ether

出典と根拠

ORDレコード
ord-b7fec6b979644c45868240396b343456
出典データセット
uspto-grants-1995_05
特許番号
US05420348

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