Ethyl N-methylaminoacetate hydrochloride → N-Methyl-N-[2-(2,4,6-trimethylphenyl)-2-cyanovinyl]-glycine ethyl ester

HRID 376491

反応式

HRID 376491 の反応式
[CH:1]([CH:3]([C:6]1[C:11]([CH3:12])=[CH:10][C:9]([CH3:13])=[CH:8][C:7]=1[CH3:14])[C:4]#[N:5])=O.Cl.[CH2:16]([O:18][C:19](=[O:23])[CH2:20][NH:21][CH3:22])[CH3:17]>C1C=CC=CC=1>[CH2:16]([O:18][C:19](=[O:23])[CH2:20][N:21]([CH3:22])[CH:1]=[C:3]([C:6]1[C:11]([CH3:12])=[CH:10][C:9]([CH3:13])=[CH:8][C:7]=1[CH3:14])[C:4]#[N:5])[CH3:17]

参加物

4

反応物 2

HCID 171173Ethyl N-methylaminoacetate hydrochlorideHCID 224743973-Oxo-2-(2,4,6-trimethyl-phenyl)-propionitrile

生成物 1

HCID 54495113N-Methyl-N-[2-(2,4,6-trimethylphenyl)-2-cyanovinyl]-glycine ethyl ester

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

A mixture of a-formyl-2,4,6 trimethylphenylacetonitrile (4.5 g, 24 mmol) and sarcosine ethyl ester hydrochloride (3.7 g, 24 mmol) in 100 mL of benzene was refluxed in a Dean-Stark apparatus for 16 h. The solvent was removed in vacuo to afford N-Methyl-N-[2-(2,4,6-trimethylphenyl)-2-cyanovinyl]-glycine ethyl ester as a pale yellow oil.

後処理

  1. temperaturewas refluxed in a Dean-Stark apparatus for 16 h
  2. customThe solvent was removed in vacuo

出典と根拠

ORDレコード
ord-9f07f7596cc6487eb7a338c6a776959a
出典データセット
uspto-grants-2000_02
特許番号
US06020492

関連ノート

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