3-Dipropylamino-5-acetylchroman → 3-Dipropylamino-5-isopropenylchroman
反応式
[Li][CH2:2]CCC.[CH2:6]([N:9]([CH2:23][CH2:24][CH3:25])[CH:10]1[CH2:19][C:18]2[C:13](=[CH:14][CH:15]=[CH:16][C:17]=2[C:20](=O)[CH3:21])[O:12][CH2:11]1)[CH2:7][CH3:8]>[Br-].C[P+](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.C(OCC)C>[CH2:6]([N:9]([CH2:23][CH2:24][CH3:25])[CH:10]1[CH2:19][C:18]2[C:13](=[CH:14][CH:15]=[CH:16][C:17]=2[C:20]([CH3:2])=[CH2:21])[O:12][CH2:11]1)[CH2:7][CH3:8]参加物
5
実験手順
Methyltriphenylphosphoniumbromide (0.62 g, 1.74 mmol) was dissolved in dry ethyl ether (20 ml) under nitrogen at ambient temperature and n-BuLi (0.7 ml, 2.5M, 1.74 mmol) was added and the solution was stirred for 4 hours. 3-Dipropylamino-5-acetylchroman (Example 7; 0.40 g, 1.45 mmol) was dissolved in dry diethyl ether (2.0 ml) and this solution was added to the previously formed Wittig-reagent.