関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Isophytol | HCID 10453 | — |
| 反応物 | Trimethylhydroquinone | HCID 12785 | — |
| 触媒 | Zinc | HCID 23994 | — |
| 触媒 | Zinc bromide | HCID 10421208 | — |
| 生成物 | DL-alpha-Tocopherol | HCID 2116 | 100.6% |
反応手順
To a mixture consisting of 69.9 g (0.460 mol) of 2,3,5-trimethylhydroquinone, 69.7 g (0.31 mol) of zinc bromide, 7.5 g of concentrated hydrochloric acid and 1.2 g of zinc dust, was added dropwise, under stirring at 50° C. over 1 hour, 138.8 g (0.460 mol) of isophytol (purity: 98.1%). Further, the resulting mixture was stirred at the same temperature for 1 hour. The reaction liquid was washed with water, followed by concentrating, whereby 199.4 g of the title compound was obtained as a brown oil (yield: 98.6%, GLC purity: 97.8%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06020505 |
|---|
| 出典データセット | uspto-grants-2000_02 |
|---|
| ORD ID | ord-32d493fdda2f4156bc1505db5a2e2309 |
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| 出典メモ | uspto-grants-2000_02 |
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