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Methyl chloroformate → 2-Methyl-1-naphthol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl chloroformate | HCID 6586 | — |
| 反応物 | 1-Hydroxy-2-naphthoic acid | HCID 6844 | — |
| 反応物 | 1-Naphthol | HCID 7005 | — |
| 反応物 | Sodium borohydride | HCID 4311764 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 溶媒 | Triethylamine | HCID 8471 | — |
| 生成物 | 2-Methyl-1-naphthol | HCID 24055 | 80% |
反応手順
1-naphthol (5) was heated with twice its weight of KHCO3 at 200° C. for 5 hours (stainless steel bomb) whereby 1-hydroxy-2-naphthoic acid (9) was obtained in a yield of 60%. 1-Hydroxy-2-naphthoic acid (9) was treated with methyl chloroformate and triethylamine in THF, followed by sodium borohydride reduction, whereby 2-methyl-naphthol (I) was produced in a yield of 80%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05420362 |
| 出典データセット | uspto-grants-1995_05 |
| ORD ID | ord-9268980dbcd94c068c537f2d13247f9b |
| 出典メモ | uspto-grants-1995_05 |