6-Hydroxyquinoline → Methyl 4-(6-quinolyloxy)-3-methylsulfonylbenzoate

HRID 376906ノート

反応式

HRID 376906 の反応式
Cl[C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][C:3]=1[S:12]([CH3:15])(=[O:14])=[O:13].[OH:16][C:17]1[CH:18]=[C:19]2[C:24](=[CH:25][CH:26]=1)[N:23]=[CH:22][CH:21]=[CH:20]2.C([O-])([O-])=O.[K+].[K+].C([O-])(O)=O.[Na+]>CN(C=O)C>[N:23]1[C:24]2[C:19](=[CH:18][C:17]([O:16][C:2]3[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][C:3]=3[S:12]([CH3:15])(=[O:14])=[O:13])=[CH:26][CH:25]=2)[CH:20]=[CH:21][CH:22]=1

参加物

6

反応物 4

HCID 113746-HydroxyquinolineHCID 11430Potassium CarbonateHCID 516892Sodium BicarbonateHCID 10490815Methyl 4-chloro-3-(methylsulfonyl)benzoate

生成物 1

HCID 19360547Methyl 4-(6-quinolyloxy)-3-methylsulfonylbenzoate

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

2 mmol of methyl 4-chloro-3-methylsulfonylbenzoate, 2 mmol of 6-hydroxyquinoline and 6 mmol of K2CO3 were stirred at 130° C. for 2 h in 20 ml of DMF (anhydrous). The mixture was then poured into 100 ml of saturated aqueous NaHCO3 solution and extracted 3 times with 100 ml of EA. The extract was dried over Na2SO4, the solvent was removed in vacuo and the product was reacted further without further purification.

後処理

  1. extractionextracted 3 times with 100 ml of EA
  2. dry with materialThe extract was dried over Na2SO4
  3. customthe solvent was removed in vacuo
  4. customthe product was reacted further without further purification

出典と根拠

ORDレコード
ord-71fa8c9e10a242cd8f2ee19a388c4e94
出典データセット
uspto-grants-2000_02
特許番号
US06022899

反応ノート

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