Ethanol → Vinylpentafluorocyclopropane
反応式
[OH-].[K+].C(O)C.Br[CH2:7][CH2:8][C:9]1([F:16])[C:11]([F:13])([F:12])[C:10]1([F:15])[F:14]>O>[CH:8]([C:9]1([F:16])[C:11]([F:13])([F:12])[C:10]1([F:15])[F:14])=[CH2:7]参加物
5
反応条件
- 温度
- 70 °C
実験手順
To a stirred solution of 18.0 g of KOH, 15 mL of ethanol and 20 mL of water was slowly added 24.0 g of 2-bromo-1-(pentafluorocyclopropyl)ethane at 70° C. During the addition, volatiles were collected in a -78° C. trap. After the addition was complete, the reaction mixture was stirred at 70° C. for an additional two hours until collection of all volatiles, which was distilled to give 9.1 g of product, bp 30° C. 19F NMR: -152.3 (dt, J=195.4 Hz, J=9.8 Hz, 2F), -156.0 (dm, J=195.6 Hz, 2F), -210.7 (t, J=7.7 Hz, 1F). 1H NMR: 5.86-5.73 (m, 2H), 5.70-5.65 (m, 1H).
後処理
- customat 70° C
- additionDuring the addition, volatiles
- customwere collected in a -78° C. trap
- additionAfter the addition
- distillationwas distilled
出典と根拠
- ORDレコード
- ord-a9b607544a9e4ac98f1a05236fb53595
- 出典データセット
- uspto-grants-1995_05
- 特許番号
- US05420367
反応ノート
読み込み中…