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Hydrochloric Acid → 3-(4-nitrophenyl)-2-hydroxy-N-(2-aminoethyl)propionamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Nitric Acid | HCID 944 | — |
| 反応物 | Atrolactic acid | HCID 1303 | — |
| 反応物 | Ethylenediamine | HCID 3301 | — |
| 反応物 | Methyl-p-nitrophenyl lactate | HCID 56998982 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 溶媒 | Sulfuric Acid | HCID 1118 | — |
| 生成物 | 3-(4-nitrophenyl)-2-hydroxy-N-(2-aminoethyl)propionamide | HCID 19360733 | — |
反応手順
Phenyl-lactic acid (available from Aldrich Chemical Co., Milwaukee, Wis.) is nitrated with nitric acid in sulfuric acid. P-nitrophenyl lactic acid is esterified with methanol and gaseous hydrochloric acid. Methyl-p-nitrophenyl lactate is condensed with ethylene diamine to provide the amide adduct, 3-(4-nitrophenyl)-2-hydroxy-N-(2-aminoethyl)propionamide.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06022966 |
| 出典データセット | uspto-grants-2000_02 |
| ORD ID | ord-1457048d56e0407caf57f36a180c5d16 |
| 出典メモ | uspto-grants-2000_02 |