Water → 2-Cyclopropylethyl methanesulfonate

To a solution of 2-cyclopropylethanol (2.1 g, 24.4 mmol) in dichloromethane (50 ml) at 0° C. under nitrogen was added triethylamine (4.1 ml, 1.3 mol equiv). Methanesulphonyl chloride (2.5 ml, 1.3 mol equiv) was added dropwise and the reaction stirred for 16 hours at room temperature. Water (30 ml) and dichloromethane (30 ml) were added. The organic phase was washed with water (2×50 ml) and then dried over anhydrous MgSO4. The solution was then filtered and the solvent removed in vacuo to give the title compound as an oil (4.0 g).

1. washThe organic phase was washed with water (2×50 ml)
2. dry with materialdried over anhydrous MgSO4
3. filtrationThe solution was then filtered
4. customthe solvent removed in vacuo

ORDレコード

ord-a4311a0b0e1b4e95834ba5370e1644a0

出典データセット

uspto-grants-2000_02

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US06022971