Hydrogen Cyanide → 3-Cyano-3,5,5-trimethylcyclohexanone

関与物質

反応条件

反応手順

622 g (4.5 mol) of isophorone and 3.61 g (25.8 mmol) of 1,3-dimethylimidazolium-4-carboxylate were placed in a reaction vessel and a mixture of 207.3 g (1.5 mol) of isophorone and 81.0 g (3 mol) of hydrogen cyanide was added at 120° C. over a period of about 60 minutes. The mixture was subsequently stirred further for about 60 minutes at 120° C. After cooling, the HCN concentration was determined by titration. Free hydrocyanic acid could no longer be detected (HCN conversion>99.9%). After addition of 2.0 g of 85% strength H3PO4, the reaction product was distilled at 0.1 hPa. This gave 484 g of 3-cyano-3,5,5-trimethylcyclohexanone (97.7% based on HCN used).

情報源と証拠