Hydrochloric Acid → Ethyl 4-amino-3-methoxybenzoate
反応式
[NH2:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[O:11][CH3:12].Cl.[CH3:14][CH2:15]O>>[CH2:14]([O:7][C:6](=[O:8])[C:5]1[CH:9]=[CH:10][C:2]([NH2:1])=[C:3]([O:11][CH3:12])[CH:4]=1)[CH3:15]参加物
4
実験手順
To a solution of 3.343 g (20 mmole) of 4-amino-3-methoxybenzoic acid in 200 mL EtOH is bubbled a stream of HCl gas for three minutes. The HCl saturated solution is stirred at room temperature for two days. Solvent is evaporated under vacuum and the resulting residue is dissolved in 100 mL water. The water layer is basified with K2CO3 and extracted with CH2Cl2 (3×200 mL). The combined CH2Cl2 layer is washed with saturated NaHCO3 (200 mL), brine and then dried over MgSO4, filtered and evaporated under reduced pressure to give the desired product.
後処理
- customSolvent is evaporated under vacuum
- dissolutionthe resulting residue is dissolved in 100 mL water
- extractionextracted with CH2Cl2 (3×200 mL)
- washThe combined CH2Cl2 layer is washed with saturated NaHCO3 (200 mL), brine
- dry with materialdried over MgSO4
- filtrationfiltered
- customevaporated under reduced pressure
出典と根拠
- ORDレコード
- ord-eeb55cbf41694783a377dc16cb25b25a
- 出典データセット
- uspto-grants-2000_02
- 特許番号
- US06024937
反応ノート
読み込み中…