関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Bromocyclopentane | HCID 8728 | — |
| 反応物 | tert-Butyl (4-methylphenyl)acetate | HCID 12362014 | — |
| 反応物 | Potassium tert-butoxide | HCID 23665647 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | Tert-butyl 2-cyclopentyl-2-(4-methylphenyl)acetate | HCID 15234721 | — |
反応手順
33.5 g (0.3 mol) of potassium tert-butylate are initially introduced into 100 ml of anhydrous DMF at 0° C., and 51.6 g (0.25 mol) of tert-butyl 4methylphenyl-acetate in 250 ml of anhydrous DMF are added dropwise. The mixture is stirred at 0° C. for 30 minutes, 32.2 ml (0.3 mol) of cyclopentyl bromide in 150 ml of anhydrous DMF are added dropwise at 5-15° C. and the mixture is stirred at 25° C. for 20 hours. After concentration, the residue is partitioned between water and diethyl ether and the ether phase is dried over sodium sulphate and concentrated. The product crystallizes out.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06025378 |
|---|
| 出典データセット | uspto-grants-2000_02 |
|---|
| ORD ID | ord-8a4fe0d7d6924c9aaf58e3e9983d1fa6 |
|---|
| 出典メモ | uspto-grants-2000_02 |
|---|
