Potassium Carbonate → 2-(1,2-Epoxycyclohexyl)-4,5-diphenyloxazole

HRID 377313ノート

反応式

HRID 377313 の反応式
Br[CH:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C:3]1([C:9]1[O:10][C:11]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[C:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[N:13]=1)[OH:8].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[O:8]1[CH:2]2[CH2:7][CH2:6][CH2:5][CH2:4][C:3]12[C:9]1[O:10][C:11]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[C:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[N:13]=1

参加物

4

反応物 2

HCID 11430Potassium CarbonateHCID 193585162-Bromo-1-(4,5-diphenyl-2-oxazolyl)cyclohexanol

生成物 1

HCID 184591642-(1,2-Epoxycyclohexyl)-4,5-diphenyloxazole収率 98.3%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A mixture of 2-bromo-1-(4,5-diphenyl-2-oxazolyl)-cyclohexanol (120 mg) and potassium carbonate (83 mg) in N,N-dimethylformamide (0.3 ml) was stirred at room temperature for 6 hours and partitioned between ethyl acetate and water. The organic layer was washed with brine, dried over magnesium sulfate, and evaporated in vacuo to afford 2-(1,2-epoxycyclohexyl)-4,5-diphenyloxazole (94 mg) as a pale yellow powder.

後処理

  1. custompartitioned between ethyl acetate and water
  2. washThe organic layer was washed with brine
  3. dry with materialdried over magnesium sulfate
  4. customevaporated in vacuo

出典と根拠

ORDレコード
ord-6f715285732440fca41c8f5f3e33e817
出典データセット
uspto-grants-2000_02
特許番号
US06025375

反応ノート

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