Glyceraldehyde → Ethyl acetate methanol ammonium hydroxide
反応式
[N:1]1(CC[O:8]C2C=CC(CC3C4C=CC=CC=4SC=3C3C=CC(CCN)=CC=3)=CC=2)CCCC1.[O:34]=[CH:35][CH:36]([CH2:38][OH:39])O.[C:40](O[BH-](OC(=O)C)OC(=O)C)(=[O:42])[CH3:41].[Na+]>ClCCl.CO>[NH4+:1].[OH-:8].[CH3:35][OH:34].[CH3:41][CH2:40][O:42][C:38]([CH3:36])=[O:39]参加物
5
実験手順
3-[4-[2-(1-Pyrrolidinyl)ethoxy]benzyl]-2-[4-(2-aminoethyl)phenyl]benzo[b]thiophene (113 mg) was dissolved in dichloromethane:methanol (2:1, 6.0 mL), treated with glyceraldehyde (25 mg) and sodium triacetoxyborohydride (60 mg) sequentially and allowed to stir at ambient temperature for 4 h. The reaction mixture was concentrated, and column chromatography with NH4OH:MeOH:EtOAc (3:7:90) afforded the product (56 mg).
後処理
- concentrationThe reaction mixture was concentrated
出典と根拠
- ORDレコード
- ord-1a415f14033b4c91b21f175517078ddb
- 出典データセット
- uspto-grants-2000_02
- 特許番号
- US06025382
反応ノート
読み込み中…