4-Toluenesulfonyl chloride → 1-(2-Chloroethyl)piperidine

HRID 377421

反応式

HRID 377421 の反応式
C1(C)C=CC(S([Cl:10])(=O)=O)=CC=1.[N:12]1([CH:18](O)[CH3:19])[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1>C(Cl)Cl>[Cl:10][CH2:19][CH2:18][N:12]1[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1

参加物

4

反応物 2

HCID 73974-Toluenesulfonyl chlorideHCID 30305411-(Piperidin-1-yl)ethanol

生成物 1

HCID 748271-(2-Chloroethyl)piperidine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

Into a 50 mL round bottom flask is placed 6.40 g (33.6 mmol) of p-toluenesulfonyl chloride and 25 mL of methylene chloride. The resulting solution is cooled with an ice bath as 4.00 g (31.0 mmol) of 1-piperidinoethanol in 6 mL of methylene chloride is added dropwise. After the addition is complete, the ice bath is removed and the resulting slurry is stirred for about 12 hours. The reaction mixture is concentrated on a rotary evaporator to yield a solid residue which may then be used as in Preparation 4 below.

後処理

  1. customInto a 50 mL round bottom flask is placed
  2. additionis added dropwise
  3. additionAfter the addition
  4. customthe ice bath is removed
  5. concentrationThe reaction mixture is concentrated on a rotary evaporator
  6. customto yield a solid residue which
  7. custommay then be used as in Preparation 4 below

出典と根拠

ORDレコード
ord-272121b4d9e74189a3251e5a42e2b264
出典データセット
uspto-grants-2000_02
特許番号
US06025495

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