HCID 66916713、化合物 → HCID 66916737、化合物

HRID 37744ノート

反応式

HRID 37744 の反応式
C([O:5][C:6](=[O:33])[CH2:7][N:8]([S:17]([C:20]1[CH:25]=[CH:24][C:23]([O:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)=[CH:22][CH:21]=1)(=[O:19])=[O:18])[CH2:9][C:10]([O:12]C(C)(C)C)=[O:11])(C)(C)C>C(O)=O>[O:26]([C:23]1[CH:22]=[CH:21][C:20]([S:17]([N:8]([CH2:9][C:10]([OH:12])=[O:11])[CH2:7][C:6]([OH:33])=[O:5])(=[O:19])=[O:18])=[CH:25][CH:24]=1)[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1

参加物

3

反応物 1

HCID 66916713HCID 66916713、化合物

生成物 1

HCID 66916737HCID 66916737、化合物

試薬・触媒・溶媒 1

HCID 284Formic Acid溶媒

実験手順

Compound 4a (1.02 g, 2.14 mmol) was dissolved in formic acid (10 mL) and stirred overnight at room temperature. The solid was filtered off, the filtrate was evaporated in vacuo, and co-evaporated with toluene (6×20 mL). The pure product obtained was dried overnight in high vacuum. Yield: 0.71 g, 1.95 mmol, 91% (off-white solid). 1H-NMR (DMSO-d6): δ 7.91 (d, 2H, 3JHH=9.0 Hz, ArH), 7.20 (d, 2H, 3JHH=9.0 Hz, ArH), 7.28 (d, 2H, 3JHH=9.0 Hz, ArH), 7.00 (d, 1H, 3JHH=9.0 Hz, ArH), 6.87 (d, 2H, 3JHH=9.0 Hz, ArH), 4.07 (s, 4H, 2×CH2CO2H).

後処理

  1. filtrationThe solid was filtered off
  2. customthe filtrate was evaporated in vacuo
  3. customThe pure product obtained
  4. customwas dried overnight in high vacuum

出典と根拠

ORDレコード
ord-a06dae072eb2430396e7a4c03ad82404
出典データセット
uspto-grants-2013_09
特許番号
US08524194B2

反応ノート

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