化工社化工社 化学情報印刷レポート · 研究参考用
Ethanol → 9-(1H-imidazol-1-yl)methyl-4-[(2-phenylethyl)amino]imidazo[5,1-h]pteridin-6(5H)-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethanol | HCID 702 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 4,6-Dichloro-5-nitropyrimidine | HCID 20312 | — |
| 反応物 | Stannous Chloride | HCID 24479 | — |
| 反応物 | N-Benzylphenethylamine | HCID 65055 | — |
| 反応物 | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| 反応物 | 2-(1H-imidazol-1-ylmethyl)-1H-imidazole | HCID 19358846 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 生成物 | 9-(1H-imidazol-1-yl)methyl-4-[(2-phenylethyl)amino]imidazo[5,1-h]pteridin-6(5H)-one | HCID 9908192 | — |
反応手順
Prepared by treatment of 4,6-dichloro-5-nitropyrimidine with N-benzylphenethylamine, followed by reaction with 2-((1H-imidazol-1-yl)methyl)imidazole, reduction with tin (II) chloride, cyclization with carbonyidiimidazole and hydrogenation with palladium on carbon in ethanol containing 1.1 eq. NaOH at 50° C. and 50 psi.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06025489 |
| 出典データセット | uspto-grants-2000_02 |
| ORD ID | ord-c05bad6c92b345d388ba0759b01712cc |
| 出典メモ | uspto-grants-2000_02 |