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Hydrochloric Acid → 8-Ethyl-4-[(2-(diethylamino)ethyl)amino]imidazo[2,1-h]pteridin-6(5H)-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 4,6-Dichloro-5-nitropyrimidine | HCID 20312 | — |
| 反応物 | Stannous Chloride | HCID 24479 | — |
| 反応物 | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| 反応物 | Benzyl[2-(diethylamino)ethyl]amine | HCID 296044 | — |
| 反応物 | HCID 178437183 | HCID 178437183 | — |
| 生成物 | 8-Ethyl-4-[(2-(diethylamino)ethyl)amino]imidazo[2,1-h]pteridin-6(5H)-one | HCID 19358886 | — |
反応手順
Prepared by reaction of 4,6-dichloro-5-nitropyrimidine with N,N-diethyl-N'-benzylethylenediamine, followed by displacement with 4-ethylimidazole, reduction with tin (II) chloride, cyclization with carbonyidiimidazole and debenzylation with 6 N HCl.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06025489 |
| 出典データセット | uspto-grants-2000_02 |
| ORD ID | ord-b993a095a3d545f780eed3380a8ee346 |
| 出典メモ | uspto-grants-2000_02 |