Hydrochloric Acid → 2-Oxo-4-phenyl-1,2-dihydroquinoline-3-carboxylic acid

HRID 377588ノート

反応式

HRID 377588 の反応式
C([O:3][C:4]([C:6]1[C:7](=[O:22])[NH:8][C:9]2[C:14]([C:15]=1[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[CH:13][CH:12]=[CH:11][CH:10]=2)=[O:5])C.C(O)C.[OH-].[K+].Cl>O>[C:16]1([C:15]2[C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[NH:8][C:7](=[O:22])[C:6]=2[C:4]([OH:5])=[O:3])[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14797Potassium HydroxideHCID 151627361,2-Dihydro-4-phenyl-2-oxo-3-quinoline carboxylic acid ethyl ester

生成物 1

HCID 151627412-Oxo-4-phenyl-1,2-dihydroquinoline-3-carboxylic acid収率 93.1%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 1,2-dihydro-4-phenyl-2-oxo-3-quinoline carboxylic acid ethyl ester (5 g, 17 mmol), ethanol (20 ml), water (40 ml) and potassium hydroxide (5 g, 89 mmol) was refluxed with heat for 1.5 hours. To the reaction mixture was added 60 ml of 2N-HCl to acidify the mixture to obtain a precipitated crystal by filtration. The crystal obtained was recrystallized from ethanol to give 4.2 g (yield: 92.9%) of the title compound.

後処理

  1. temperaturewas refluxed
  2. temperaturewith heat for 1.5 hours
  3. customto obtain a precipitated crystal
  4. filtrationby filtration
  5. customThe crystal obtained
  6. customwas recrystallized from ethanol

出典と根拠

ORDレコード
ord-0f95c03dc4e044c591d3c74b3172fdd9
出典データセット
uspto-grants-2000_02
特許番号
US06028079

反応ノート

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