1,4-Dibromobutane → 7-(4-Bromobutoxy)-3-piperidino-2,2-dimethylbenzofuran

HRID 3776

反応式

HRID 3776 の反応式
[OH-].[K+].[OH:3][C:4]1[C:12]2[O:11][C:10]([CH3:14])([CH3:13])[CH:9]([N:15]3[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]3)[C:8]=2[CH:7]=[CH:6][CH:5]=1.[Br:21][CH2:22][CH2:23][CH2:24][CH2:25]Br>[Cl-].C([N+](CCCC)(CCCC)CCCC)CCC.CCOCC>[Br:21][CH2:22][CH2:23][CH2:24][CH2:25][O:3][C:4]1[C:12]2[O:11][C:10]([CH3:13])([CH3:14])[CH:9]([N:15]3[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]3)[C:8]=2[CH:7]=[CH:6][CH:5]=1

参加物

6

反応物 3

HCID 80561,4-DibromobutaneHCID 14797Potassium HydroxideHCID 141266507-Hydroxy-3-piperidino-2,2-dimethylbenzofuran

生成物 1

HCID 212890017-(4-Bromobutoxy)-3-piperidino-2,2-dimethylbenzofuran

試薬・触媒・溶媒 2

HCID 70681Tetrabutylammonium Chloride触媒HCID 3283Diethyl Ether溶媒2 回

実験手順

Crushed potassium hydroxide (19.6 g) and tetrabutyl ammonium chloride (1.7 g) are added to a solution of 7-hydroxy-3-piperidino-2,2-dimethylbenzofuran (14.4 g) in 1,4-dibromobutane (69.4 ml) and the mixture stirred at RT under nitrogen for 5 hours. The reaction mixture is diluted with ether, washed with water, extracted with 5% aq. HCl and the acidic phase washed with ether. The acidic phase is made basic thereby forming an oil which is taken up in ether, washed with sat'd aq. NaCl, dried, filtered and evaporated in vacuo affording the desired product as a liquid.

後処理

  1. washwashed with water
  2. extractionextracted with 5% aq. HCl
  3. washthe acidic phase washed with ether
  4. customThe acidic phase is made basic thereby forming an oil which
  5. washwashed with sat'd aq. NaCl
  6. customdried
  7. filtrationfiltered
  8. customevaporated in vacuo

出典と根拠

ORDレコード
ord-e1cc7aae472c4f0e89601c6881976e37
出典データセット
uspto-grants-1988_02
特許番号
US04722925

関連ノート

読み込み中…