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Bromomethyl acetate → 5,6-Dichloro-1-[6-[1-(acetyloxy)methyl-2-methylpyridinium-3-yl-oxy]pyridin-3-ylcarbamoyl]indoline chloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Bromomethyl acetate | HCID 68536 | — |
| 反応物 | Sodium Tetraphenylborate | HCID 2723787 | — |
| 反応物 | 5,6-Dichloro-1-[6-(2-methylpyridin-3-yloxy)pyridin-3-ylcarbamoyl]indoline | HCID 19356259 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 5,6-Dichloro-1-[6-[1-(acetyloxy)methyl-2-methylpyridinium-3-yl-oxy]pyridin-3-ylcarbamoyl]indoline chloride | HCID 19356266 | 80% |
反応手順
5,6-Dichloro-1-[6-(2-methylpyridin-3-yloxy)pyridin-3-ylcarbamoyl]indoline (0.25 g, 0.6 mmol) was treated with bromomethyl acetate and sodium tetraphenylboron at reflux in acetonitrile (15 ml) for 10 h according to the procedure described in Example 1 to give the title compound (E3) (0.26 g, 80%) m.p. 125-135° C. which contained approximately 15% starting material as an off-white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06028085 |
| 出典データセット | uspto-grants-2000_02 |
| ORD ID | ord-346548e1d75c495b94bdc8b45954bf80 |
| 出典メモ | uspto-grants-2000_02 |