化工社化工社 化学情報印刷レポート · 研究参考用
Triethylamine → 3-(4-Trifluoromethylbenzamido)propan-1-ol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 3-Amino-1-propanol | HCID 9086 | — |
| 反応物 | 4-(Trifluoromethyl)benzoyl chloride | HCID 67607 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 3-(4-Trifluoromethylbenzamido)propan-1-ol | HCID 22006830 | 85% |
反応手順
A reaction vessel was charged with 7.51 g of 3-amino-1-propanol, 2.53 g of triethylamine and 50 ml of dichloromethane, and 5.21 g of 4-trifluoromethylbenzoyl chloride was slowly added dropwise under ice cooling. After stirring at room temperature for 6 hours, the reaction mixture was successively washed with diluted hydrochloric acid and water, dried over anhydrous magnesium sulfate, and then concentrated, which afforded 5.25 g of 3-(4-trifluoromethylbenzamido)propan-1-ol (85% yield).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06028100 |
| 出典データセット | uspto-grants-2000_02 |
| ORD ID | ord-67b8943e2bab437695ddc76cdbffb0e8 |
| 出典メモ | uspto-grants-2000_02 |