化工社化工社 化学情報印刷レポート · 研究参考用
CID 367964 → 3-(4-Fluorophenyl)-2-methylpropanoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | CID 367964 | HCID 367964 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 3-(4-Fluorophenyl)-2-methylpropanoic acid | HCID 15487791 | — |
反応手順
5% Pd/C (11.0 g) is added to p-fluoro-α-methylcinnamic acid (177.9 g, 0.987 mol) in 3.6 l ethanol. The mixture is hydrogenated at room temperature at 40 p.s.i. When the hydrogen uptake ceases, the catalyst is filtered off, and the filtrate is concentrated in vacuo to give the product, p-fluoro-α-methylhydrocinnamic acid, which is used without weighing in the next step.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06028116 |
| 出典データセット | uspto-grants-2000_02 |
| ORD ID | ord-a801ed2c651849f5bf6530bfe49a45db |
| 出典メモ | uspto-grants-2000_02 |