化工社化工社 化学情報印刷レポート · 研究参考用
Oxalyl chloride → (Z)-1-(4-Methylsulfonylbenzylidene)-5-dimethylamino-2-methyl-3-indenylacetyl chloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Oxalyl chloride | HCID 65578 | — |
| 反応物 | (Z)-1-(p-methylsulfonylbenzylidene)-5-dimethylamino-2-methyl-3-indenylacetic acid | HCID 70288307 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | (Z)-1-(4-Methylsulfonylbenzylidene)-5-dimethylamino-2-methyl-3-indenylacetyl chloride | HCID 86755163 | — |
反応手順
(Z)-1-(p-methylsulfonylbenzylidene)-5-dimethylamino-2-methyl-3-indenylacetic acid (70 mmol) in THF (500 ml) is allowed to react with oxalylchloride (2 M in CH2Cl2 ; 70 mmol) under reflux conditions (24 hours). The solvent is evaporated to yield the title compound, which is used as such in the next step.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06028116 |
| 出典データセット | uspto-grants-2000_02 |
| ORD ID | ord-e2929b27588e4b1888b43b4c40832e59 |
| 出典メモ | uspto-grants-2000_02 |