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Potassium Carbonate → 3-[3-[4-(2-Aminothiazol-4-yl)-4-phenylpiperid-1-yl-]propyl]-1-benzoyl-3-(3,4-dichlorophenyl)perhydroazepine dihydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 1-Benzoyl-3-(3,4-dichlorophenyl)-3-[3-(methanesulfonyloxy)propyl]-perhydroazepine | HCID 21702966 | — |
| 反応物 | 4-(2-Aminothiazol-4-yl)-4-phenylpiperidine | HCID 22741726 | — |
| 溶媒 | acetonitrile N,N-dimethylformamide | HCID 21891449 | — |
| 生成物 | 3-[3-[4-(2-Aminothiazol-4-yl)-4-phenylpiperid-1-yl-]propyl]-1-benzoyl-3-(3,4-dichlorophenyl)perhydroazepine dihydrochloride | HCID 22741719 | — |
反応手順
This compound is prepared by the procedure described in step D of EXAMPLE 13, starting from 0.77 g of 4-(2-aminothiazol-4-yl)-4-phenylpiperidine (compound of PREPARATION 1.4 in the form of the free base), 1.2 g of the compound obtained in step C of EXAMPLE 13 and 1.2 g of K2CO3 in 20 ml of a DMF/acetonitrile mixture (50150; v/v). This gives 0.8 g of the expected product after crystallization from AcOEt, m.p.=178° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06028082 |
| 出典データセット | uspto-grants-2000_02 |
| ORD ID | ord-107075cb2b854d639293ddf7d85ca7ca |
| 出典メモ | uspto-grants-2000_02 |