Dichloromethane → Phenyl N-(4,5-dimethyl-2-methoxyphenyl)thiocarbamate

HRID 377924ノート

反応式

HRID 377924 の反応式
C[C:2]1[C:3]([O:10][CH3:11])=[C:4]([CH:6]=[CH:7][C:8]=1[CH3:9])[NH2:5].[CH2:12](Cl)Cl.[CH:15]1[CH:20]=[CH:19][C:18]([O:21][C:22](Cl)=[S:23])=[CH:17][CH:16]=1>O>[CH3:9][C:8]1[C:7]([CH3:12])=[CH:6][C:4]([NH:5][C:22](=[S:23])[O:21][C:18]2[CH:19]=[CH:20][CH:15]=[CH:16][CH:17]=2)=[C:3]([O:10][CH3:11])[CH:2]=1

参加物

5

反応物 3

HCID 6344DichloromethaneHCID 70498Phenyl thioxochloroformateHCID 178964772-Methoxy-3,4-dimethylaniline

生成物 1

HCID 53857756Phenyl N-(4,5-dimethyl-2-methoxyphenyl)thiocarbamate収率 92%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To 3,4-dimethyl-2-methoxyaniline(4.50 g, 0.03 mol), methylene chloride(100 ml) was added and then phenyl chlorothionoformate(5.16 g, 0.03 mol) was added slowly. The resulting mixture was stirred for 2 hours, and thereto water(150 ml) was added. The resulting mixture was extracted with methylene chloride and purified by column chromatography to obtain the titled compound.

後処理

  1. extractionThe resulting mixture was extracted with methylene chloride
  2. custompurified by column chromatography

出典と根拠

ORDレコード
ord-4ed0aabd626a4eeeb2ae2dba8c03d4fc
出典データセット
uspto-grants-2000_02
特許番号
US06028195

反応ノート

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