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Triethylamine → 2-methylthio-2-imidazoline N-ethylcarbamate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Ethyl chloroformate | HCID 10928 | — |
| 反応物 | Hydrogen iodide | HCID 24841 | — |
| 反応物 | 2-Methylthio-2-imidazoline hydroiodide | HCID 88369 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 2-methylthio-2-imidazoline N-ethylcarbamate | HCID 86755173 | — |
反応手順
To 2-methylthio-2-imidazoline.HI (Aldrich) (10 g, 0.041 mole) and triethylamine (8.3 g, 0.0082 mole) in CH2Cl2 (50 mL) was added ethylchloroformate (Aldrich) (4.5 g, 0.041 mole) dropwise at ice bath temperature. The reaction was stirred overnight at room temperature. The precipitate was filtered and washed with CH2Cl2. The CH2Cl2 from the filtrate was washed with H2O (3×), dried over MgSO4 and removed under vacuum to yield 2-methylthio-2-imidazoline-N-ethylcarbamate (7.1 g) as a clear yellow oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06028223 |
| 出典データセット | uspto-grants-2000_02 |
| ORD ID | ord-f00a8f047563487b9aac4f53e5631c5c |
| 出典メモ | uspto-grants-2000_02 |