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Hydrochloric Acid → 4-Piperidinecarboxylic acid, 1-methyl-, hydrochloride (1:1)
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Ethyl 1-methylpiperidine-4-carboxylate | HCID 11062856 | — |
| 生成物 | 4-Piperidinecarboxylic acid, 1-methyl-, hydrochloride (1:1) | HCID 2760043 | 48% |
反応手順
A solution of 1-methyl-piperidine-4-carboxylic acid ethyl ester (2.0 g, 11.7 mmol) in conc. hydrochloric acid (20 mL) was heated to 100° C. and maintained for 6 h. The mixture was then concentrated to dryness in vacuo to give a solid, which was washed with acetonitrile-diethyl ether (1:1) and dried in vacuo to afford 1-methyl-piperidine-4-carboxylic acid hydrochloride (1.0 g, 48%) as an off-white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08524705B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-b2d4f887d1504bc6ae79c363e192ce23 |
| 出典メモ | uspto-grants-2013_09 |