Hydrochloric Acid → 4-Piperidinecarboxylic acid, 1-methyl-, hydrochloride (1:1)

HRID 37818

反応式

HRID 37818 の反応式
C([O:3][C:4]([CH:6]1[CH2:11][CH2:10][N:9]([CH3:12])[CH2:8][CH2:7]1)=[O:5])C.[ClH:13]>>[ClH:13].[CH3:12][N:9]1[CH2:10][CH2:11][CH:6]([C:4]([OH:5])=[O:3])[CH2:7][CH2:8]1

参加物

3

反応物 2

HCID 313Hydrochloric AcidHCID 11062856Ethyl 1-methylpiperidine-4-carboxylate

生成物 1

HCID 27600434-Piperidinecarboxylic acid, 1-methyl-, hydrochloride (1:1)収率 48%

実験手順

A solution of 1-methyl-piperidine-4-carboxylic acid ethyl ester (2.0 g, 11.7 mmol) in conc. hydrochloric acid (20 mL) was heated to 100° C. and maintained for 6 h. The mixture was then concentrated to dryness in vacuo to give a solid, which was washed with acetonitrile-diethyl ether (1:1) and dried in vacuo to afford 1-methyl-piperidine-4-carboxylic acid hydrochloride (1.0 g, 48%) as an off-white solid.

後処理

  1. temperaturemaintained for 6 h
  2. concentrationThe mixture was then concentrated to dryness in vacuo
  3. customto give a solid, which
  4. washwas washed with acetonitrile-diethyl ether (1:1)
  5. customdried in vacuo

出典と根拠

ORDレコード
ord-b2d4f887d1504bc6ae79c363e192ce23
出典データセット
uspto-grants-2013_09
特許番号
US08524705B2

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