4-Methyl-2-nitroaniline → 2-Nitro-4-toluonitrile

HRID 378328

反応式

HRID 378328 の反応式
[CH3:1][C:2]1[CH:8]=[CH:7][C:5](N)=[C:4]([N+:9]([O-:11])=[O:10])[CH:3]=1.[C-:12]#[N:13].[Na+]>[O-]S([O-])(=O)=O.[Cu+2]>[CH3:1][C:2]1[CH:8]=[CH:7][C:5]([C:12]#[N:13])=[C:4]([N+:9]([O-:11])=[O:10])[CH:3]=1

参加物

4

反応物 2

HCID 69784-Methyl-2-nitroanilineHCID 8929Sodium Cyanide

生成物 1

HCID 962352-Nitro-4-toluonitrile

試薬・触媒・溶媒 1

HCID 24462Copper Sulfate触媒

実験手順

11.75 g (77.2 mmol) of 4-methyl-2-nitroaniline underwent a Sandmeyer reaction in a conventional process by diazotization and substitution with NaCN and CuSO4 to give 9.6 g of crude 4-methyl-2-nitrobenzonitrile. 1H-NMR (DMSO-d6, δ in ppm): 8.25 (1H), 8.05 (1H), 7.80 (1H), 2.50 (3H)

出典と根拠

ORDレコード
ord-1b522b4234d046afb932a038441e9a2f
出典データセット
uspto-grants-2000_02
特許番号
US06030972

関連ノート

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