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Acetic Acid → Methyl 5-(2,4-dioxothiazolidin-5-ylidene)methyl-2-methoxybenzoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | Thiazolidinedione | HCID 5437 | — |
| 反応物 | Ammonium Acetate | HCID 517165 | — |
| 反応物 | Methyl 5-formyl-2-methoxybenzoate | HCID 10856352 | — |
| 溶媒 | Benzene | HCID 241 | — |
| 生成物 | Methyl 5-(2,4-dioxothiazolidin-5-ylidene)methyl-2-methoxybenzoate | HCID 54363563 | 86% |
反応手順
A mixture of methyl 5-formyl-2-methoxybenzoate (490 mg), thiazolidine-2,4-dione (358 mg), ammonium acetate (401 mg), acetic acid (0.8 ml) and benzene (10 ml) was submitted to Dean-Stalk dewatering apparatus to reflux for 4 hours under heat. After cooling, the crystals deposited were collected by filtration, washed with benzene and with 20% aqueous solution of acetone, and then dried to obtain 634 mg (86%) of aimed compound as crystals.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06030990 |
| 出典データセット | uspto-grants-2000_02 |
| ORD ID | ord-03287fb8b777420db9a2b3b5043438ca |
| 出典メモ | uspto-grants-2000_02 |