4-Bromophenol → Methyl 3-(4-bromophenoxy)-3-phenyl-2-hydroxybutyrate

反応式

[Br:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.[C:9]1([C:15]2([CH3:22])[O:21][CH:16]2[C:17]([O:19][CH3:20])=[O:18])[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:15]([C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=2)([CH3:22])[CH:16]([OH:21])[C:17]([O:19][CH3:20])=[O:18])=[CH:4][CH:3]=1

参加物

反応物 2

HCID 78084-Bromophenol

HCID 228011Methyl 3-methyl-3-phenyloxirane-2-carboxylate

生成物 1

HCID 15292297Methyl 3-(4-bromophenoxy)-3-phenyl-2-hydroxybutyrate収率 20%

実験手順

51.9 g (0.3 mol) of 4-bromophenol and 19.2 g (0.1 mol) of methyl 3-phenyl-2,3-epoxybutyrate are stirred at 100° C. for 8 hours and at room temperature for 12 hour. After removal of the excess phenol by distillation, the residue is purified by flash chromatography (silica gel, n-hexane/ethyl acetate 9:1) to result in 7.2 g of a white solid.

後処理

customAfter removal of the excess phenol
distillationby distillation
customthe residue is purified by flash chromatography (silica gel, n-hexane/ethyl acetate 9:1)

出典と根拠

ORDレコード: ord-d9675b544e26491989ee50b08f760dbe
出典データセット: uspto-grants-2000_02
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06030975

反応ノート

読み込み中…

参加物