Methyl 4-(2,2-dimethoxyethyl)-3-nitrobenzoate → Methyl 3-amino-4-(2,2-dimethoxyethyl)benzoate
反応式
[CH3:1][O:2][CH:3]([O:18][CH3:19])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]([O:13][CH3:14])=[O:12])=[CH:7][C:6]=1[N+:15]([O-])=O>CO>[CH3:19][O:18][CH:3]([O:2][CH3:1])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]([O:13][CH3:14])=[O:12])=[CH:7][C:6]=1[NH2:15]参加物
3
実験手順
4-Carbomethoxy-2-nitrophenylacetaldehyde dimethylacetal (8.75 g, 41.43 mmole) was reduced under hydrogen (50 psi, 0.45 g of 10% Pd/carbon) in 170 mL of methanol for 2.5 h. The solution was filtered through celite and evaporated to an oil. Crystallization from ether and hexanes gave 6.16 g of 2-amino4-carbomethoxy-phenylacetaldehyde dimethylacetal.
後処理
- filtrationThe solution was filtered through celite
- customevaporated to an oil
- customCrystallization from ether and hexanes
出典と根拠
- ORDレコード
- ord-2e4cc4ff3fd440cb933a628667e6fc52
- 出典データセット
- uspto-grants-2000_02
- 特許番号
- US06030994
反応ノート
読み込み中…