t-butoxycarbonyl-N-(6-methoxy-6-oxohexyl)-L-phenylalaninamide → N-(6-methoxy-6-oxohexyl)-L-phenylalaninamide monohydrochloride

HRID 3784

反応式

HRID 3784 の反応式
C(OC([NH:8][C@H:9]([C:17]([NH:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][C:25]([O:27][CH3:28])=[O:26])=[O:18])[CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=O)(C)(C)C.[ClH:29].O1CCOCC1>O1CCOCC1>[ClH:29].[CH3:28][O:27][C:25](=[O:26])[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20][NH:19][C:17](=[O:18])[C@H:9]([CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[NH2:8]

参加物

4

反応物 2

HCID 12799279t-butoxycarbonyl-N-(6-methoxy-6-oxohexyl)-L-phenylalaninamideHCID 204431481,4-Dioxane hydrochloride

生成物 1

HCID 70402980N-(6-methoxy-6-oxohexyl)-L-phenylalaninamide monohydrochloride

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

To a solution of the title compound of Example 2 (43.1 g, 0.11 mole) in 100 ml of dioxane was added 100 ml of 6M hydrogen chloride/dioxane. After about 30 min. the solution was concentrated in vacuo to dryness and the residue triturated thoroughly with diethyl ether. The solid was collected and washed well with diethyl ether, giving 34.7 g of the title compound, which was used in subsequent reactions without further purification.

後処理

  1. concentrationAfter about 30 min. the solution was concentrated in vacuo to dryness
  2. customthe residue triturated thoroughly with diethyl ether
  3. customThe solid was collected
  4. washwashed well with diethyl ether

出典と根拠

ORDレコード
ord-dfc940d1027e4824b71c811ac0ae7fe4
出典データセット
uspto-grants-1988_02
特許番号
US04722922

関連ノート

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