1,4-Dioxane → 1-(4-Aminophenyl)piperidin-4-one

HRID 37847

反応式

HRID 37847 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][C:13](=[O:16])[CH2:12][CH2:11]2)=[CH:6][CH:5]=1)([O-])=O.O1CCOCC1>[Ni].CO>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:11][CH2:12][C:13](=[O:16])[CH2:14][CH2:15]2)=[CH:6][CH:5]=1

参加物

5

反応物 2

HCID 312751,4-DioxaneHCID 38425621-(4-Nitrophenyl)piperidin-4-one

生成物 1

HCID 222202411-(4-Aminophenyl)piperidin-4-one収率 55.5%

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 887Methanol溶媒

実験手順

A solution of 1-(4-nitro-phenyl)-piperidin-4-one (2.8 g, 12.7 mmol) in a mixture of 1:4 dioxane: methanol (100 mL) was hydrogenated over Raney nickel (1 g) under balloon pressure at ambient temperature overnight. The mixture was filtered through Celite and the filtrate was concentrated under vacuum. The resulting solid was washed with petroleum ether (2×10 mL) and dried to afford 1-(4-amino-phenyl)-piperidin-4-one (1.34 g, 55%).

後処理

  1. filtrationThe mixture was filtered through Celite
  2. concentrationthe filtrate was concentrated under vacuum
  3. washThe resulting solid was washed with petroleum ether (2×10 mL)
  4. customdried

出典と根拠

ORDレコード
ord-9fd9cdc746864c5e85abe82bcbb9f9cc
出典データセット
uspto-grants-2013_09
特許番号
US08524705B2

関連ノート

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