2,4,5-Trichlorobenzenesulfonyl chloride → 2,4,5-Trichloro-N-(4-bromo-3-methyl-5-isoxazolyl)benzenesulfonamide

反応式

[NH2:1][C:2]1[O:6][N:5]=[C:4]([CH3:7])[C:3]=1[Br:8].[Cl:9][C:10]1[CH:15]=[C:14]([Cl:16])[C:13]([Cl:17])=[CH:12][C:11]=1[S:18](Cl)(=[O:20])=[O:19]>>[Cl:9][C:10]1[CH:15]=[C:14]([Cl:16])[C:13]([Cl:17])=[CH:12][C:11]=1[S:18]([NH:1][C:2]1[O:6][N:5]=[C:4]([CH3:7])[C:3]=1[Br:8])(=[O:20])=[O:19]

参加物

反応物 2

HCID 275752,4,5-Trichlorobenzenesulfonyl chloride

HCID 104875194-Bromo-3-methylisoxazol-5-amine

生成物 1

HCID 186172862,4,5-Trichloro-N-(4-bromo-3-methyl-5-isoxazolyl)benzenesulfonamide収率 67%

実験手順

2,4,5-Trichloro-N-(4-bromo-3-methyl-5-isoxazolyl)benzenesulfonamide was prepared from 5-amino-4-bromo-3-methylisoxazole and 2,4,5-trichlorobenzenesulfonyl chloride according to the procedures described in Example 30. The crude product was purified by recrystallization from ethyl acetate/hexanes to give a crystalline solid, m.p. 179-182° C., yield 67%.

後処理

customThe crude product was purified by recrystallization from ethyl acetate/hexanes
customto give a crystalline solid, m.p. 179-182° C., yield 67%

出典と根拠

ORDレコード: ord-3e3c6d3cebdb48c893139c026fd35837
出典データセット: uspto-grants-2000_02
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06030991

反応ノート

読み込み中…

参加物