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Dimethylformamide → 8-(4-Benzyloxy-phenyl)-7-oxo-7H-thieno[2,3-a]quinolizine-10-carboxylic acid isopropyl-(2-methoxy-ethyl)-amide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | N-(2-Methoxyethyl)isopropylamine | HCID 551575 | — |
| 反応物 | 8-[p-(benzyloxy)phenyl]-7-oxo-7H-thieno[2,3-a]quinolizine-10-carboxylic acid | HCID 19353629 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 溶媒 | Triethylamine | HCID 8471 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | 8-(4-Benzyloxy-phenyl)-7-oxo-7H-thieno[2,3-a]quinolizine-10-carboxylic acid isopropyl-(2-methoxy-ethyl)-amide | HCID 56629768 | — |
反応手順
From 8-[p-(benzyloxy)phenyl]-7-oxo-7H-thieno[2,3-a]quinolizine-10-carboxylic acid with SOCl2 and DMF in toluene. Then treatment with triethylamine and isopropyl-(2-methoxy-ethyl)-amine in dioxan.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06030984 |
| 出典データセット | uspto-grants-2000_02 |
| ORD ID | ord-11e1f58d569448248917e951548596ef |
| 出典メモ | uspto-grants-2000_02 |