Hydrochloric Acid → Acridine

HRID 378755

反応式

HRID 378755 の反応式
[NH:1]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:4](=O)[C:2]1=O.Cl>[OH-].[K+].O>[CH:4]1[CH:2]=[C:2]2[CH:4]=[C:6]3[C:11](=[N:1][C:8]2=[CH:7][CH:6]=1)[CH:10]=[CH:9][CH:8]=[CH:7]3

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 7054Isatin

生成物 1

HCID 9215Acridine

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 14797Potassium Hydroxide溶媒

実験手順

The isatin product from step (a) was refluxed in 300 mL of 10% KOH solution in water for ca. 48 h. The solution was cooled and acidified to pH 2-3 with HCl. The yellow solid was suction filtered after 1 h and then washed with water. The solid was air-dried over night, washed with CH2Cl2 and then air-dried yielding 23.76 g of the acridine acid. 1H NMR (DMSO-d6) δ 7.72-8.30 (m, 7H).

後処理

  1. temperatureThe solution was cooled
  2. filtrationfiltered after 1 h
  3. washwashed with water
  4. customThe solid was air-dried over night
  5. washwashed with CH2Cl2
  6. customair-dried

出典と根拠

ORDレコード
ord-e4e9027484294c6a9c469c5a4841e8ab
出典データセット
uspto-grants-2001_10
特許番号
US06296787B1

関連ノート

読み込み中…