Ammonium Hydroxide → 4-Amino-3,5,6-trifluoro-2-cyanopyridine
反応式
[F:1][C:2]1[C:3]([C:11]#[N:12])=[N:4][C:5]([F:10])=[C:6]([F:9])[C:7]=1F.[OH-].[NH4+:14]>CN(C=O)C.O>[NH2:14][C:7]1[C:6]([F:9])=[C:5]([F:10])[N:4]=[C:3]([C:11]#[N:12])[C:2]=1[F:1]参加物
5
実験手順
To a solution of 3,4,5,6-tetrafluoro-2-cyanopyridine in DMF (75 mL) at 0C was slowly added concentrated ammonium hydroxide (15 mL). The reaction was stirred and additional 15 min and the solution was diluted with water (150 mL). The solid was collected and air dried to give 4-amino-3,5,6-trifluoro-2-cyanopyridine (25.5 g, 0.16 mol, 92%); mp 291-30 C.
後処理
- customThe solid was collected
- customair dried
出典と根拠
- ORDレコード
- ord-863ffce9f2b545329952788ae4bad168
- 出典データセット
- uspto-grants-2001_10
- 特許番号
- US06297197B1
反応ノート
読み込み中…