関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Dimethylformamide diethylacetal | HCID 70913 | — |
| 反応物 | Ethyl 2-(6-chloropyridin-3-yl)acetate | HCID 15661146 | — |
| 生成物 | Ethyl 2-(6-chloropyridin-3-yl)-3-(dimethylamino)acrylate | HCID 72537728 | — |
反応手順
3.99 g (20.0 mmol) of the compound from Example 1A are dissolved in 13.7 ml of dimethylformamide diethyl acetal, and the mixture is stirred with microwave irradiation at 90° C. for 30 min. The mixture is then concentrated on a rotary evaporator, and the residue is chromatographed on silica gel 60 (mobile phase: dichloromethane→dichloromethane/methanol 20:1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08524699B2 |
|---|
| 出典データセット | uspto-grants-2013_09 |
|---|
| ORD ID | ord-16cc391b4b8f4a33be01b15eb6e4129f |
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| 出典メモ | uspto-grants-2013_09 |
|---|
