Hydrazine → Pyrazine-2-Carboxylic Acid Hydrazide
反応式
[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[C:7]([O:9]C)=O.[NH2:11][NH2:12]>CO>[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[C:7]([NH:11][NH2:12])=[O:9]参加物
4
実験手順
To a solution of the product from Example 1 step c) (22 g, 159 mmol) in methanol (250 ml) was slowly added hydrazine monhydrate (36.6 ml, 710 mmol). The reaction mixture was stirred for 1.5 h. The precipitate produced was filtered, washed with diethyl ether and dried in the oven at 80° C. to give the required product (30 g). 1H NMR (250 MHz, DMSO) δ 4.66 (2H, broad peak), 8.66 (1H, m), 8.84 (1H, d, J=2.5 Hz), 9.13 (1H, d, J=2.5 Hz), 10.15 (1H, broad peak); MS (ES+) m/e 139 [MH+].
後処理
- customThe precipitate produced
- filtrationwas filtered
- washwashed with diethyl ether
- customdried in the oven at 80° C.
出典と根拠
- ORDレコード
- ord-8880dd93059d499192c4c6be784ff1e1
- 出典データセット
- uspto-grants-2001_10
- 特許番号
- US06297235B1
反応ノート
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