Hydrazine → Pyrazine-2-Carboxylic Acid Hydrazide

HRID 378833

反応式

HRID 378833 の反応式
[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[C:7]([O:9]C)=O.[NH2:11][NH2:12]>CO>[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[C:7]([NH:11][NH2:12])=[O:9]

参加物

4

反応物 2

HCID 9321HydrazineHCID 72662Methyl pyrazinoate

生成物 1

HCID 258796Pyrazine-2-Carboxylic Acid Hydrazide

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of the product from Example 1 step c) (22 g, 159 mmol) in methanol (250 ml) was slowly added hydrazine monhydrate (36.6 ml, 710 mmol). The reaction mixture was stirred for 1.5 h. The precipitate produced was filtered, washed with diethyl ether and dried in the oven at 80° C. to give the required product (30 g). 1H NMR (250 MHz, DMSO) δ 4.66 (2H, broad peak), 8.66 (1H, m), 8.84 (1H, d, J=2.5 Hz), 9.13 (1H, d, J=2.5 Hz), 10.15 (1H, broad peak); MS (ES+) m/e 139 [MH+].

後処理

  1. customThe precipitate produced
  2. filtrationwas filtered
  3. washwashed with diethyl ether
  4. customdried in the oven at 80° C.

出典と根拠

ORDレコード
ord-8880dd93059d499192c4c6be784ff1e1
出典データセット
uspto-grants-2001_10
特許番号
US06297235B1

関連ノート

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