Dimethyl Sulfoxide → Benzyl-4-(3-chloropropyl)piperazine dihydrochloride

HRID 3789

反応式

HRID 3789 の反応式
Br[CH2:2][CH2:3][CH2:4][Cl:5].[CH2:6]([N:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.CS(C)=O.[OH-].[K+]>O>[ClH:5].[ClH:5].[CH2:6]([N:13]1[CH2:18][CH2:17][N:16]([CH2:2][CH2:3][CH2:4][Cl:5])[CH2:15][CH2:14]1)[C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1

参加物

6

反応物 4

HCID 679Dimethyl SulfoxideHCID 80061-Bromo-3-chloropropaneHCID 14797Potassium HydroxideHCID 759941-Benzylpiperazine

生成物 1

HCID 13731110Benzyl-4-(3-chloropropyl)piperazine dihydrochloride収率 163.9%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

31.5 g of 1-bromo-3-chloropropane were added to a mixture of 35 g of 1-benzylpiperazine, 150 ml of dimethyl sulfoxide and 25 g of potassium hydroxide. The resulting mixture was stirred at room temperature for 3 hours. Water was added to the resulting solution, the reaction product was extracted with ether, dried (magnesium sulfate), and the salt was precipitated with ethereal hydrochloric acid to give 35.6 g (55% of theory) of 1-benzyl-4-(3-chloropropyl)piperazine dihydrochloride as a white crystalline solid.

後処理

  1. extractionthe reaction product was extracted with ether
  2. dry with materialdried (magnesium sulfate)
  3. customthe salt was precipitated with ethereal hydrochloric acid

出典と根拠

ORDレコード
ord-93fa51c8f7084cf4905f1b5a5619a265
出典データセット
uspto-grants-1988_02
特許番号
US04722926

関連ノート

読み込み中…