Ethanol → Ethyl 2-(5-bromopyridin-3-yl)acetate

HRID 37893

反応式

HRID 37893 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([OH:11])=[O:10])[CH:5]=[N:6][CH:7]=1.[CH2:12](O)[CH3:13]>S(=O)(=O)(O)O>[Br:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH:5]=[N:6][CH:7]=1

参加物

4

反応物 2

HCID 702EthanolHCID 28025392-(5-Bromopyridin-3-yl)acetic acid

生成物 1

HCID 54116619Ethyl 2-(5-bromopyridin-3-yl)acetate

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid触媒

実験手順

5.0 g (23.1 mmol) of (5-bromopyridin-3-yl)acetic acid in 30 ml of ethanol and 25 drops of conc. sulfuric acid are stirred at boiling point for 16 h. For work-up, the reaction mixture is concentrated under reduced pressure, the residue is taken up in ethyl acetate and washed repeatedly with semiconcentrated sodium bicarbonate solution, the organic phase is dried over sodium sulfate, the drying agent is filtered off, the solvent is removed completely on a rotary evaporator and the product is dried under reduced pressure for 16 h.

後処理

  1. customfor 16 h
  2. concentrationFor work-up, the reaction mixture is concentrated under reduced pressure
  3. washwashed repeatedly with semiconcentrated sodium bicarbonate solution
  4. dry with materialthe organic phase is dried over sodium sulfate
  5. filtrationthe drying agent is filtered off
  6. customthe solvent is removed completely on a rotary evaporator
  7. customthe product is dried under reduced pressure for 16 h.

出典と根拠

ORDレコード
ord-e24430d98d0a4aaf9fb307533163ce10
出典データセット
uspto-grants-2013_09
特許番号
US08524699B2

関連ノート

読み込み中…