Water → 1-Methylsulfonyloxy-5-phenylpentane

HRID 378973ノート

反応式

HRID 378973 の反応式
[C:1]1([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][OH:12])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(N(CC)CC)C.[CH3:20][S:21](Cl)(=[O:23])=[O:22].O>C(Cl)Cl>[C:1]1([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][O:12][S:21]([CH3:20])(=[O:23])=[O:22])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

6

反応物 4

HCID 962WaterHCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 615235-Phenyl-1-pentanol

生成物 1

HCID 116301071-Methylsulfonyloxy-5-phenylpentane収率 100.6%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

5-Phenyl-pentanol (40 g, 244 mmoles) in methylene chloride (80 ml) at 0° C. was added with triethylamine (39 ml, 28.34 g, 280 mmoles) and a solution of methyl-sulfonyl chloride (20.7 ml, 30.69 g, 268 mmoles) in methylene chloride (40 ml). The temperature was left to rise to the room value, then the mixture was poured into water and the organic phase was isolated, washed with water, anhydrified and concentrated to give 59.49 g of the title product (yield: 99%).

後処理

  1. waitThe temperature was left
  2. customthe organic phase was isolated
  3. washwashed with water, anhydrified
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-23c3cb3c1e2c4f0389ecf98416913ab2
出典データセット
uspto-grants-2001_10
特許番号
US06297257B1

反応ノート

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