Hydrochloric Acid → HCID 178479414、化合物
反応式
[NH:1]([C:5]1[S:6][CH:7]=[C:8]([C:10]([NH:12][C:13]2[CH:25]=[CH:24][C:16]([O:17][CH2:18][C:19]([O:21]CC)=[O:20])=[CH:15][CH:14]=2)=[O:11])[N:9]=1)[C:2]([NH2:4])=[NH:3].[ClH:26]>>[ClH:26].[NH:1]([C:5]1[S:6][CH:7]=[C:8]([C:10]([NH:12][C:13]2[CH:25]=[CH:24][C:16]([O:17][CH2:18][C:19]([OH:21])=[O:20])=[CH:15][CH:14]=2)=[O:11])[N:9]=1)[C:2]([NH2:4])=[NH:3]参加物
3
実験手順
227 mg of ethyl {4-[(2-guanidino-thiazole-4-carbonyl)-amino]-phenoxy}-acetate are stirred for 3 days at RT in 25% hydrochloric acid. The precipitate is filtered off under suction, washed with water, triturated in methanol, filtered off under suction and dried. There are obtained 165 mg of [4-[(2-guanidino-thiazole-4-carbonyl)- amino]-phenoxy]-acetic acid hydrochloride (1:1); m.p. 278° C., MS: 336 (M+H)+.
後処理
- filtrationThe precipitate is filtered off under suction
- washwashed with water
- customtriturated in methanol
- filtrationfiltered off under suction
- customdried