Imidazole → 2-Hydroxy-4-imidazol-1-ylmethyl-benzonitrile

HRID 379031ノート

反応式

HRID 379031 の反応式
Br[CH2:2][C:3]1[CH:10]=[CH:9][C:6]([C:7]#[N:8])=[C:5]([OH:11])[CH:4]=1.[NH:12]1[CH:16]=[CH:15][N:14]=[CH:13]1>CN(C=O)C>[OH:11][C:5]1[CH:4]=[C:3]([CH2:2][N:12]2[CH:16]=[CH:15][N:14]=[CH:13]2)[CH:10]=[CH:9][C:6]=1[C:7]#[N:8]

参加物

4

反応物 2

HCID 795ImidazoleHCID 216969934-(Bromomethyl)-2-hydroxybenzonitrile

生成物 1

HCID 216970282-Hydroxy-4-imidazol-1-ylmethyl-benzonitrile

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

4-bromomethyl-2-hydroxy-benzonitrile (0.22 g, 1.05 mmol) and imidazole (0.36 g, 5.23 mmol) were dissolved in DMF (10 mL) with stirring at ambient temperature. After stirring for 18 h, the reaction mixture was concentrated in vacuo and purified by silica gel chromatography eluting with 2% CH3OH/CH2C12 to 5% CH3OH/CH2Cl2 to give the title compound.

後処理

  1. stirringAfter stirring for 18 h
  2. concentrationthe reaction mixture was concentrated in vacuo
  3. custompurified by silica gel chromatography
  4. washeluting with 2% CH3OH/CH2C12 to 5% CH3OH/CH2Cl2

出典と根拠

ORDレコード
ord-b0d36694988949c584188e150db9557d
出典データセット
uspto-grants-2001_10
特許番号
US06297239B1

反応ノート

読み込み中…