関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | o-Iodoanisole | HCID 68257 | — |
| 反応物 | HCID 178516071 | HCID 178516071 | — |
| 触媒 | Copper | HCID 23978 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 2(1H)-Pyridinone, 1-(2-methoxyphenyl)- | HCID 12191389 | — |
反応手順
2-Iodoanisole (1.30 mL, 0.01 mol), 2-hydroxypyridine (0.95 g, 0.01 mol), anhydrous K2CO3 (2.76 g, 0.02 mol) and copper powder (0.0636 g, 0.001 mol) were combined and heated at 200° C. for 2 hr. The reaction mixture was cooled, EtOAc added, and filtered. The filtrate was washed with H2O, aqueous saturated NaHCO3 solution, brine, and dried (Na2SO4). Filtration and concentration gave the title compound after chromatography (silica gel, 2% CH3OH, CH2Cl2).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06297239B1 |
|---|
| 出典データセット | uspto-grants-2001_10 |
|---|
| ORD ID | ord-4c3a55ba796041aab00b78a70ae21ba3 |
|---|
| 出典メモ | uspto-grants-2001_10 |
|---|
