関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Cesium carbonate | HCID 10796 | — |
| 反応物 | 2-(2-oxo-2H-pyridin-1-yl)-phenol | HCID 21697056 | — |
| 反応物 | Benzonitrile, 2-fluoro-4-(1H-imidazol-1-ylmethyl)- | HCID 21697068 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 4-Imidazol-1-ylmethyl-2-[2-(2-oxo-2H-pyridin-1-yl)-phenoxy]-benzonitrile | HCID 9951152 | — |
反応手順
2-Fluoro-4-imidazol-1-ylmethyl-benzonitrile (as described in Example 9, Step E) (0.0276 g, 0.137 mmol), 2-(2-oxo-2H-pyridin-1-yl)-phenol (0.0257 g, 0.137 mmol) and cesium carbonate (0.089 g, 0.274 mmol) were combined in DMF (1.2 mL) and heated at 70° C. for 18 hr. The title compound was obtained after RP HPLC on aWaters Prep Pak column eluting with a 0.1% TFA/H2O: 0.1% TFA/CH3CN gradient followed by conversion to the free base.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06297239B1 |
|---|
| 出典データセット | uspto-grants-2001_10 |
|---|
| ORD ID | ord-899750f8795945f4ba7065d7861781cd |
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| 出典メモ | uspto-grants-2001_10 |
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